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Designing Innovative Interventions to End the AIDS Epidemic
PERC Nepal is actively contributing to ending the AIDS epidemic by designing and implementing innovative programs and interventions. These efforts address the numerous challenges faced by populations affected by HIV. The PERC team has been deeply involved in assessing the public health burden, from psychosocial and mental health issues to drug resistance, among key populations and people living with HIV. In addition to assessment, the team evaluates existing programs and interventions targeting key and vulnerable populations. This evaluation aims to modify or introduce highly effective interventions that align with achieving global targets to end AIDS and viral hepatitis. The focus also extends to measuring the burden of common, curable sexually transmitted infections (STIs) such as syphilis and gonorrhea among key populations. PERC supports the design and implementation of targeted programs to address these burdens effectively. Below are some notable projects and publications from the PERC team that highlight their contributions to addressing these critical health issues.
Pioneering Digital Transformation: From Paper-Based to Tablet-Based HIV Surveillance in Nepal
Biological and Behavioral Surveillance (BBS) surveys are essential for tracking key indicators among populations at higher risk of HIV, including people who inject drugs, men who have sex with men, transgender individuals, se...
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Unveiling the Hidden Challenges: Psychosocial Health, Service Access, and HIV Risk Among Sexual and Gender Minorities in Nepal
Dr. Keshab Deuba, the Senior Health Advisor at PERC, received funding in 2009/2010 through the Netherlands Development Organization (SNV) and the Social Inclusion Research Fund (SIRF), Nepal, supported by the Norwegian Embass...
Read MoreGlobal, regional, and national burden of tuberculosis and multidrug-resistant tuberculosis by HIV status, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
In 2023, there were an estimated 9·11 million (95% uncertainty interval 8·04–10·3) incident cases of all-form TB, 1·22 million (0·98–1·49) deaths, and 54·6 million (43·8–65·5) DALYs globally. HIV-related TB comprised 781 000 (690 000–879 000) incident cases and 210 000 (142 000–279 000) deaths, contributing 11·0 mil...
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(26)00295-1/abstractHigh-Risk Sexual Contacts in Nepal and India Among Male Labor Migrants: Findings from the 2024 National Survey in Nepal
AbstractThe first national HIV bio-behavioral survey in men who work as migrant laborers in India was conducted in 2024 in all seven provinces in Nepal. We aimed to determine the levels of risky sexual behaviors, including contacts with female sex workers (FSW). Household-level multi-stage cluster-based sampling was used to recruit 1872 male labor...
https://link.springer.com/article/10.1007/s10508-026-03455-9Readiness of health facilities to provide HIV testing and counseling and TB services in Nepal: Findings from a 2021 Nepal Health Facility Survey
Abstract Introduction HIV and Tuberculosis (TB) are major public health challenges in Nepal, requiring well-prepared health systems to provide effective care. We assessed the readiness of Nepal’s health facilities to provide HIV testing and counseling (HTC) and TB services. Methods We conducted a secondary analysis of 359 health faci...
https://www.sciencedirect.com/science/article/pii/S2949856225001126Determinants of loss to follow-up among people living with HIV receiving antiretroviral therapy in a universal test and treat setting: A retrospective cohort study in Nepal
Objectives This study aims to assess the cumulative incidence and rate of loss to follow-up (LTFU) among people living with HIV (PLHIV) in Nepal who begin antiretroviral therapy (ART) early, as well as to identify factors associated with LTFU in the context of the universal test and treat approach. Study design Retrospective cohort study....
https://www.sciencedirect.com/science/article/pii/S2666535225000539Progress Toward the Elimination of Vertical HIV Transmission in Nepal: A Retrospective Cohort Study
Despite global advancements, pregnant women living with HIV in Nepal remain at risk for vertical transmission. This study examined demographic and clinical characteristics, antiretroviral therapy (ART) retention, and transmission outcomes among this population. A retrospective cohort analysis was conducted using data from Nepal’s national electr...
https://link.springer.com/article/10.1007/s10900-025-01474-6Disease Burden Attributed to Drug use in the Nordic Countries: a Systematic Analysis for the Global Burden of Diseases, Injuries, and Risk Factors Study 2019
Abstract The Nordic countries share similarities in many social and welfare domains, but drug policies have varied over time and between countries. We wanted to compare differences in mortality and disease burden attributed to drug use over time. Using results from the Global Burden of Disease (GBD) study, we extracted age-standardized estimate...
https://link.springer.com/article/10.1007/s11469-023-01131-wSurvival on antiretroviral treatment among adult HIV-infected patients in Nepal: a retrospective cohort study in Far-western Region, 2006- 2011.
BMC Infectious Diseases. December 2013
http://www.ncbi.nlm.nih.gov/pubmed/24369908Prevalence of HIV, Hepatitis C and its related risk behaviours among women who inject drugs in the Kathmandu Valley, Nepal: a cross-sectional study.
Adv Infect Dis. 2021 Jan-Dec; 8: 20499361211062107 Abstract Background: People who inject drugs (PWID) are at great risk of HIV and Hepatitis C Virus (HCV). In order to properly design interventions and develop programmes for women who inject drugs, this study assessed the prevalence of HIV, Hepatitis B, Hepatitis C, and syphilis and its...
https://pmc.ncbi.nlm.nih.gov/articles/PMC8646840/Prevalence of viral load suppression and acquired drug resistance among people living with HIV in Nepal: a nationally representative surveillance study.
J GLOB ANTIMICROB RESIST. 2023;35:122-127. PMID: 37709138, ABSTRACT Objectives This is the first nationally representative study to estimate the prevalence of viral load (VL) suppression and acquired HIV drug resistance (ADR) among people living with HIV (PLHIV) in Nepal. Methods A cross-sectional study recruited 1418 PLHIV fr...
https://www.sciencedirect.com/science/article/pii/S2213716523001522High Interest in the Use of mHealth Platform for HIV Prevention among Men Who Have Sex with Men in Nepal.
J COMMUNITY HEALTH. 2024:1-13. PMID: 38281283, DOI: 10.1007/s10900-024-01324-x Abstract Mobile technology growth in Nepal offers promising opportunities for using mobile health (mHealth) interventions to facilitate HIV prevention efforts. However, little is known about access and utilization of communication technology and their w...
https://link.springer.com/article/10.1007/s10900-024-01324-x
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